Radiation therapy can be used for palliation in cases of metastatic deposits causing mass effect and related symptoms (e.g. spinal cord compression, subcutaneous lesions or lymph nodes that have grown through the skin, compression of major vessels or airways).  In the setting of isolated metastatic disease, stereotactic body radiation therapy (SBRT) may be considered for increased local control.  Early referral to multidisciplinary palliative care services has been associated with better patient outcomes, including improve quality of life and in some cancer types, improved survival [54,55].