Systemic Therapy (Chemotherapy)

Systemic therapy is any type of cancer treatment that travels in your blood and around your body. Chemotherapy is one type of systemic therapy.

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About systemic therapy

Systemic therapy includes many types of drug treatments that damage or kill cancer cells.  One type of systemic therapy is chemotherapy (or "chemo"). 

 Systemic therapy can:

You might have systemic therapy by itself or with other treatments such as surgery or radiation therapy.

Some cancers need only one kind of drug treatment. Other cancers might need more than one drug treatment. Your specific treatment plan is called a treatment protocol. ​

Systemic therapy can also affect normal, healthy cells. This is what causes side effects from treatment.  For more information, see  Side Effe​cts & Management​ .  ​

How systemic therapy w​orks​​

​Systemic therapy works by killing cancer cells or controlling their growth. The medication travels through your blood and all around your body. Different types of systemic therapy work in different ways. For example, immunotherapy​ uses your body's immune system to attack cancer cells while hormone therapy blocks certain hormones that help cancer cells grow. To learn more about the types of systemic therapies, click on the links below:

  • ​Chemotherapy
  • Hormone therapy
  • Immunotherapy
    • ​CAR T-cell therapy
  • ​Targeted therapy

Your course of treatment​​

Your medical oncologist, a cancer doctor who specializes in cancer drug treatments, will consider the following when deciding on your treatment:

  • ​Your type of cancer
  • Where it is in your body
  • Other treatments you have had or are going to have
  • Your overall health and fitness

Most people get systemic therapy in regular intervals called cycles. For example, you may have treatment one day every three weeks. The time between each treatment is a rest period. This allows your body to heal and recover from any side effects.

The entire course of your treatment, from the first treatment to the last, may be a few months or longer.

Your health care team will talk to you about your treatment cycles and length of treatment.

Having systemic therapy

To help you prepare for systemic therapy, please watch our video:

If you have any questions about preparing for your treatment, please talk to your cancer care team.

Before treatment s​​tarts

​Before you start systemic therapy, you may need to have some tests to make sure you are ready for treatment or to help your cancer care team decide on the best treatment for you. Your cancer care team will talk to you about any tests you might need.

Immunizations

Before starting systemic therapy, make sure your immunizations are up to date. This includes the flu vaccine.

For more information about the flu and COVID-19 vaccines:

Medications

Keep a list of any medications and supplements you are taking. Share this list with your cancer care team. Some medications do not work well together or they may affect your cancer treatment. If your medications change, tell your cancer care team.

Systemic therapy and fertility​​

Systemic therapy can affect your fertility (your ability to get pregnant, stay pregnant or get someone else pregnant). There may be things you can do to protect your fertility. Some of these things need to be done before treatment. If this is important to you, talk to your cancer care team before you start your treatment.

Advance care planning

Advance care planning (ACP) involves thinking about and writing down your wishes and instructions for your health. It includes choosing the people you want to make decisions for you, if you cannot speak for yourself.​​​

ACP is a type of life planning, like writing a will or saving for retirement. The best time to make an advance care plan is when you are healthy and can speak for yourself. 

For more information, talk to your cancer care team and visit: ​Advance Care Planning​

Preventing pregnancy during cancer treatment: what you need to know

​When having cancer treatment, it is important that you or your partner do not get pregnant.

Cancer treatments, like radiation and systemic therapy (chemotherapy, immunotherapy, hormone or targeted therapy) may damage eggs, an embryo (very early part of pregnancy), a fetus (unborn baby), or sperm.

If you can get pregnant, your healthcare team will offer to do a pregnancy test before treatment starts. This test is done with your agreement.​

If you think you might be pregnant at any time before or during your cancer treatment, tell your cancer care team right away.

Scheduling your tre​​atments​

Once you and your medical oncologist have decided that you are ready for treatment, your first treatment will be scheduled.  You will get a call letting you know the time of your first treatment.  If your treatment is only pills that you swallow, we will call you with an appointment time to meet with a BC Cancer pharmacist.

Having treat​ment

Most types of systemic therapy are delivered at a BC Cancer regional centre or a hospital/clinic near your home.  You may be referred by your medical oncologist to a hospital or clinic closer to your home. This way, you will not have to travel to get treatment.

If you need to travel for treatment, talk to your cancer care team. You can also visit our Transportation & Lodging​ page.

We usually give systemic therapy in one of four ways:

Intravenously (IV) at a BC Cancer regional centre or community hospital/clinic

  • ​A needle attached to a tube is put ​into your vein. The drug treatment travels through the needle into your vein.
  • If you get treatment this way, we will give you an appointment date and time. A nurse will give you the treatment. The nurse will also talk with you about your treatment and any side effects you may have. 
  • IV treatment can take anywhere from several minutes, to several hours, to a full day.  It depends on your treatment. 
  • If your treatment will take many hours, consider bringing items to stay comfortable:
    • ​Headphones, a smart phone or tablet, a charger for your device.
    • Books, magazines, or e-reader
    • A blanket, sweater, slippers/warm socks and a toque or hat
    • Water bottle and snacks​

IV infusion pump that you take home

Pills

  • ​Some drug treatments are pills that you swallow.
  • If you get treatment this way, we will give you an appointment date and time to meet with a BC Cancer pharmacist. The pharmacist will explain your treatment, talk about side effects and give you the pills you need.

Injection

Other ways of getting treatment

​Some people may get treatment in a way not listed above. These are less common. For example, some people may get eye drops. Your cancer care team will explain your treatment and answer your questions.
Types of systemic therapy

There are four main types of systemic therapy. Depending on your cancer type, stage of your cancer and how you are feeling, your medical oncologist will decide what type of systemic therapy is right for you.

Click on the links below to learn more:

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