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BC Cancer Pathology Reviews

Updated March 2018

BC Cancer breast pathologists can be asked to review slides in the following situations:

  1. It is the suggestion of the BC Cancer Breast Tumour Group to consider a formal pathology review for node negative invasive breast cancers in which  a change in pathology could significantly change the prognosis of the  breast cancer and initiate a change in clinical management. 
  2. Cases in which clarification of specific aspects of the tumour would impact treatment decisions, e.g. margin size, can be reviewed prior to a final decision regarding treatment.  These reviews are typically requested as needed by a treating oncologist - radiation, medical, or surgical.
References

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  12. 1Bloom HJG, Richardson WW. Histologic grading and prognosis in breast cancer: A study of 1709 cases of which 359 have been followed for 15 years. Br J Cancer 1957;2:353-377.
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  37. Pinder SE, et al. Pathological prognostic factors in breast cancer. III. Vascular invasion. Relationship with recurrence and survival in a large study with long-term follow-up. Histopathol 1994;24:41-47.
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  43. Gonzalez-Vela MC, et al. Predictors of axillary lymph node metastases in patients with invasive breast carcinoma by a combination of classical and biological prognostic factors. Pathol Res Pract 1999;195:611-618.
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  50. Soler AP, et al. P-cadherin expression in breast carcinoma indicates poor survival. Cancer 19999;86:1263-1272.
  51. Tan DSP, et al. The biological and prognostic significance of cell polarity and E-cadherin in Grade I infiltrating ductal carcinoma of the breast. J Pathol 1999;189:20-27.
  52. Gonzalez MA, et al. An immunohistochemical examination of the expression of E-cadherin, alpha- and beta/gamma- catenins and alpha2- and beta1- integrins in invasive breast cancer. J Pathol 1999;187:523-529.
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Lobular carcinoma

  1. Dixon JM, et al. Infiltrating lobular carcinoma of the breast. Histopathology 1982;6:149-161.
  2. DiCostanzo D et al. Prognosis of infiltrating lobular carcinoma. An analysis of "classical" and variant tumors. Am J Surg Pathol 1990;14:12-23.
  3. Fechner RE. Histological variants of infiltrating lobular carcinoma of the breast. Hum Pathol 1975;6:373-378.
  4. Fisher ER, et al. Tubulolobular invasive breast cancer: a variant of lobular invasive cancer. Hum Pathol 1977;8:679-683.
  5. Weidner N, Semple JP. Pleomorphic variant of invasive lobular carcinoma of the breast. Hum Pathol 1992;23:1167-1171.
  6. Eusebi V, et al. Pleomorphic lobular carcinoma of the breast: An aggressive tumour showing apocrine differentiation. Hum Pathol 1992;23:655-662.
  7. Frost AR. The significance of signet-ring cells in infiltrating lobular carcinoma of the breast. Arch Pathol Lab Med 1995;119:64-68.

DCIS Grading

  1. Schnitt SJ, et al. Developing a Prognostic index for ductal carcinoma in situ of the breast. Are we there yet? Cancer 1996;77:2189-2192.
  2. Silverstein MJ, et al. A prognostic index for ductal carcinoma in situ of the breast. Cancer 1996;77:2267-2274.
  3. Silverstein MJ, et al. Prognostic classification of breast ductal carcinoma in situ. Lancet 1995;345:1154-1157.
  4. Fisher ER, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) protocol B-17. Intraductal carcinoma (ductal carcinoma in situ). Cancer 1995;75:1310-1319.
  5. Holland R, et al. Microcalcification associated with ductal carcinoma in situ: mammographic-pathologic correlation. Semin Diagn Pathol 1994;11:181-192
  6. Holland R, et al. Ductal carcinoma in situ: a proposal for a new classification. Semin Diagn Pathol 1994;11:167-180.
  7. Leal CB, et al. Ductal carcinoma in situ of the breast; histological categorization and its relationship to ploidy, and immunohistochemical expression of hormone receptors, p54, and c-erbB-2 protein. Cancer 1995;75:2123-2131.
  8. Sneige N, et al. Ductal carcinoma in situ treated with lumpectomy and irradiation: histopathological analysis of 49 specimens with emphasis on risk factors and long term results. Hum Pathol 1995;26:642-649.
  9. Douglas-Jones AG, et al. A critical appraisal of six modern classifications od ductal carcinoma in situ of the breast (DCIS): correlation with grade of associated invasive carcinoma. Histopathology 1996;29:397-409.
  10. Consensus conference on the classification of ductal carcinoma in situ. Human Pathology 1997;28:1221-1225.

Estrogen Receptors

  1. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Modern Pathology 1998;11(2):155-168
  2. Leake R, et al. Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. J Clin Pathol 2000;53:634-635
  3. Pertschuk LP, et al. Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic and biochemical correlations and relationship to endocrine response and survival. Cancer 1990;66:1633-1670.
  4. Pertschuk LP, et al. Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Spgamma in frozen sections or cytosol-based ligand assays. Cancer 1996;77:2514-2519.
  5. Andersen J, et al. Immunohistochemical estrogen receptor determination in paraffin-embedded tissue. Prediction of response to hormone treatment in advanced breast cancer. Cancer 1989;64:1901-1908.
  6. Goulding H, et al. A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples. Human Pathol 1995;26:291-294.
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